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KMID : 0603820070130030175
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Journal of Experimental & Biomedical Science
2007 Volume.13 No. 3 p.175 ~ p.182
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In vitro Retention of Antimicrobial Activity of Ciprofloxacin-incorporated Central Venous Catheters
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Jeon Sung-Min
Kim Mal-Nam
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Abstract
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In vitro ciprofloxacin (CFX)-release study and bioassay using microorganisms were performed to estimate the retention of the antimicrobial activity of the CFX-incorporated central venous catheters (CFX-CVCs). The release experiments were carried out under the optional CFX-release conditions to mimic the in vivo environment. The release of CFX experienced an initial burst followed by a slow and steady matrix-diffusion controlled release. The 1.0CP (polyurethane catheter containing 1.0% (w/w) of CFX) under dynamic condition showed a near zero-order CFX release profile, which is beneficial for the long-tenn antimicrobial activity. The modified Kirby-Bauer method was performed employing S. aureus and E. coli to evaluate the retention of antimicrobial activity of the catheters retrieved from the release experiments. The 1.0CP showed the long-term antimicrobial activity ({geq};21 days) against both S. aureus and E. coli. These results indicate that 1.0CP is useful as a long-tenn indwelling CVC.
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KEYWORD
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Central venous catheters (CVCs), Ciprofloxacin (CFX), Infections, Release profile, Long-term antimicrobial activity
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